... Over time, limited blood flow may lead to retinal damage and AMD.Some studies have also found that the enzyme angiotensin II may contribute to AMD. This enzyme plays a role in forming new, abnormal blood vessels. In wet AMD, these new blood vessels leak blood and fluid into the retina. ...
... The HTRA1 gene gives instructions for making the HTRA1 enzyme. This protein helps break down larger proteins into smaller pieces. HTRA1 also blocks the effects of transforming growth factor (TGF)-beta. ...
... So far, GWAS have found more than 30 genes that raise the risk of developing this eye disease.The HTRA1 and ARMS2 Genes and AMDThe HTRA1 gene provides instructions for making the HTRA1 enzyme. This specialized protein breaks large proteins into smaller ones. HTRA1 is important for breaking down other proteins in the extracellular matrix. ...
Is Macular Degeneration Hereditary? Genes and Family Risk Factors
... So far, GWAS have found more than 30 genes that raise the risk of developing this eye disease.The HTRA1 and ARMS2 Genes and AMDThe HTRA1 gene provides instructions for making the HTRA1 enzyme. This specialized protein breaks large proteins into smaller ones. HTRA1 is important for breaking down other proteins in the extracellular matrix. ...