What a great question to be asking — staying on top of all available options is so important. Since your wife has both wet and dry AMD, her situation is more complex, and whether she's a candidate for Izervay (avacincaptad pegol) or Syfovre (pegcetacoplan) really depends on her specific diagnosis.
Both Izervay and Syfovre Show Full Answer
What a great question to be asking — staying on top of all available options is so important. Since your wife has both wet and dry AMD, her situation is more complex, and whether she's a candidate for Izervay (avacincaptad pegol) or Syfovre (pegcetacoplan) really depends on her specific diagnosis.
Both Izervay and Syfovre are FDA-approved treatments specifically for geographic atrophy (GA), which is the advanced stage of dry AMD. They work by calming overactivity in the immune system to slow the growth of atrophy and help preserve vision over time. However, there are some important things to be aware of. Both medications carry a risk of potentially converting dry AMD to wet AMD as a side effect. Since your wife already has wet AMD and is receiving anti-VEGF injections (Eylea and Vabysmo), this is a particularly important consideration her doctor would need to weigh carefully.
Other potential side effects of these GA treatments include:
- Bleeding in the eye (conjunctival hemorrhage)
- Increased eye pressure
- Blurred vision
- Floaters Given the complexity of managing both wet and dry AMD simultaneously, this is absolutely a conversation for her retinal specialist. They can assess whether she has geographic atrophy, evaluate how it might interact with her current treatments, and determine if adding one of these injections makes sense for her overall care plan.
September 7
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